Conglomerates surface in new resolution strategies
PhD ceremony: Mr. M.W. van der Meijden, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Conglomerates surface in new resolution strategies
Promotor(s): prof. A.J. Minnaard, prof. R.M. Kellogg
Faculty: Mathematics and Natural Sciences
This research covers 4 subjects. First a recently discovered process for the conversion of a conglomerate, a 50:50 mechanical mixture of enantiomers, into a single enantiomer by means of grinding of the solid while racemization occurs in solution. This technique was used in the successful synthesis of the bestselling drug, Clopidogrel (Plavix) used for treatment of high blood pressure.
Next we attempted to connect resolution agents to a surface (sort of chip) to be able to do a complete screening with many resolving agents in one experiment and in this way shorten the required time for finding the right resolution method and conditions. By using a stamp with a pattern it was possible to apply a controlled pattern of the desired compound. Several practical problems have so far hindered practical application, although highly useful insights in the field of crystallization in both 2D as 3D have been obtained.
Some members of an unusual family of chiral molecules, the helicenes characterized by their staircase-like structures, have also been investigated. An amine-compound from the family of helicenes has been synthesized via a short and scalable synthesis. It was possible to separate the enantiomers and this made it possible to study the chiral and optical properties also on gold and copper surfaces.
Finally, the synthesis of a helicene with an acid functionality has been accomplished. Many routes had to be examined before a success approach was developed. Preliminary work on the absorption of this helicene on metal surfaces has been carried out.
Last modified: | 13 March 2020 12.59 a.m. |
More news
-
24 June 2025
The search for extraterrestrial life inspires and humbles us
Our planet floats in an almost infinite void in the universe and, as far as we know, is the only planet on which life exists. Floris van der Tak, senior scientist at SRON and Professor of Astrochemistry in Groningen, is searching for life beyond our...
-
23 June 2025
Three Comenius Teaching Fellow grants for teaching innovation at Faculty of Science and Engineering
Researchers at the Faculty of Science and Engineering (RUG) have received Comenius Teaching Fellow grants from the National Educational Research Organization (NRO).
-
17 June 2025
ERC Advanced grants for three UG researchers
The European Research Council has awarded ERC Advanced grants to Prof. Inga Kamp, Prof. Wouter Roos and Prof. Syuzanna Harutyunyan.