PhD ceremony: Mr. S. Roy, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Resolving local structures and dynamics of proteins with 2D IR spectroscopy
Promotor(s): prof. J. Knoester
Faculty: Mathematics and Natural Sciences
Proteins are essential components of a living system as they perform many mechanical and bio-chemical functions that are needed for survival. For example, elastin provides elasticity and enzymes function as catalysts to activate most of the reactions in the living system.
A protein spontaneously folds into the most stable structure with minimum free energy, which is known as protein folding. It is important to understand how proteins fold, as folding into wrong structures leads to Alzheimer’s disease, Parkinson's disease, type II diabetes, and cancer. To investigate functions and folding of proteins one needs to know their structures.
Resolving protein structure at different steps of bio-chemical reactions or in a folding process is a great challenge. This is because these phenomena happen in a wide range of time scales which can be from 1/1000000000000000 of seconds (femtoseconds) to seconds. We have developed methodologies that allow to resolve proteins structures which are involved in ultrafast interconversions (time scale ~100000 femtoseconds). This is done by combining theories and computations with experiments that are performed using infrared lasers to probe molecular vibrations. The methodologies can be used to identify different intermediates and the time scales at which they interconvert in a reaction/folding pathway.
Inspired by the importance of the European Wadden Sea for migratory birds, last week China successfully nominated parts of its own Wadden Sea - in the Yellow Sea - for the Unesco World Heritage Status. This means that the list of protected areas is...
The University of Groningen (UG) and Wageningen University & Research (WUR) have decided to work together more closely in the area of nature-inclusive and circular agriculture, and the rural development associated with this, in the Northern Netherlands...
Thirteen researchers from the University of Groningen (UG) and the UMCG have been awarded Veni grants within the framework of NWO’s Innovational Research Incentives Scheme.
A terrific result building on last year's successes, where 12 Groningen researchers...