Imaging of tumor vascularization and related hypoxia. Preclinical and clinical studies

PhD ceremony: Mr. G. Mees, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Imaging of tumor vascularization and related hypoxia. Preclinical and clinical studies

Promotor(s): prof. C. van de Wiele, prof. R.A.J.O. Dierckx

Faculty: Medical Sciences

In this work, the effects of a modification of tumour oxygenation on tumour metabolism and with it the possible consequences and benefits for functional imaging using [¹⁸F]FDG-PET, were studied. Although our results suggest that [¹⁸F]FDG-uptake might reflect tumour hypoxia, the use of [¹⁸F]FDG as a reliable non-invasive marker of tumour hypoxia seems questionable.