PhD ceremony: Ms. J.V. Georgieva, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Ligand-mediated transport of drug delivery devices across the blood-brain barrier
Promotor(s): prof. D. Hoekstra
Faculty: Medical Sciences
The bottleneck for successful drug delivery into the brain is the blood-brain barrier (BBB), a physical and metabolic barrier. Nanoparticles represent drug delivery devices, that - when linked to proper targeting ligands - may penetrate the BBB and hence increase the bioavailability of medicines into the brain. Moreover, a therapeutic molecule can be incorporated in a nanoparticle, protecting if from degradation during transport to the site of action. In this project, the cellular prion protein and the monosialoganglioside GM1 as blood-brain barrier receptors were characterized regarding their potential to induce receptor-mediated transcytosis of ligand-modified nanoparticles. Novel short peptidic ligands that bind to either prion or GM1 generated phage display and grafted on the surface of polymeric nanoparticles. Nanoparticles decorated with a GM1-binding peptide showed a brain-targeting potential in vivo, together with a high transcytotic capacity in vitro and in vivo, which makes them a promising vehicle for drug delivery into the brain.
You can vote until October 5.
Dean Knoester leaves Groningen science faculty January 1, 2022
The grant of EUR 921,000 is for his project ‘Multi-scale assessment of liquid metal embrittlement at steel-zinc interfaces (MUSCLES).
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