Figure: The membrane protein (yellow) is integrated in the membranes. The transport proteins (red, purple) recognize the address label to stretch the linker; they interact subsequently to the components in the center of the pore complex. The linker slices through the scaffold.
PhD ceremony: Mr. A.C. Meinema, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: The transport of integral membrane proteins across the nuclear pore complex
Promotor(s): prof. B. Poolman
Faculty: Mathematics and Natural Sciences
Being at the right time on the right place in the cell is important for the function of proteins. This is well studied for soluble proteins transported into the nucleus of a cell. Those proteins bear a nuclear localization signal to be targeted into the nucleus. Transport proteins bind these address codes and bring the proteins from the cytoplasm across the nuclear pore complex into the nucleus.
However, it was still unknown how membrane proteins were transported into the nucleus. In my thesis, I show that the address code on membrane proteins is attached via a long and unfolded linker domain. The flexible linker can easily be stretched, so that the address code can be away from the membranes. This provides a freedom of movement to the transport protein, while it is bound to the address code. The freedom enables the transport protein to reach the center of the pore complex, while the membrane protein is still in the membranes. The membrane protein is pulled through the pore complex via the linker. The linker needs to be flexible enough to cut through the scaffold of the pore complex. This new model describes a transport route of membrane proteins into the nucleus.
Three researchers of the Faculty of Science and Engineering have been awarded an ENW-XS grant by the Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijke Onderzoek, NWO): Prof. A.I. Guskov the Groningen Biomolecular Sciences and...
Bayu Jayawardhana has been appointed scientific director of DISC, the interuniversity research institute and graduate school that unites all university groups in the Netherlands that are active in systems and control theory and engineering. The...
Researchers Clemens Mayer and Danny Incarnato of the University of Groningen have been awarded an ERC Consolidator Grant.
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