The role of growth differentiation factor 15 in diabetic kidney injury
PhD ceremony: Ms. M. Mazagová, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: The role of growth differentiation factor 15 in diabetic kidney injury
Promotor(s): prof. R.H. Henning
Faculty: Medical Sciences
The studies presented in this thesis demonstrated a profound role for GDF15 in the development of diabetic nephropathy. GDF15 expression was strongly induced in the glomerulus after induction of diabetes in rats and mice. Further, our study in GDF15 knockout and wild type mice showed that GDF15 preserved tubular function and prevented interstitial damage in both type 1 and type 2 diabetes. However, GDF15 did not protect the glomerulus from sclerosis nor did it prevent albuminuria. Furthermore, pretreatment of vessels (aortas) with GDF15 affected endothelial function resulting in impaired vascular contraction and relaxation. Finally, plasma levels of GDF15 correlated with progression of albuminuria in patients with T2DM. The notion that BMPR2 seems to be involved as a main receptor for GDF15, may facilitate development of novel therapeutic approaches to limit renal damage in diabetic patients.
Last modified: | 13 March 2020 12.59 a.m. |
More news
-
29 November 2023
UMCG opent nieuwe faciliteit voor microbioomonderzoek 
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
-
28 November 2023
Science: more exciting than showbiz
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
-
13 November 2023
UMCG beantwoordt vragen patiënten met hulp van AI
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...