Immune regulation by allergen immunotherapy. Lessons learned from experimental approaches

PhD ceremonies: Ms. S. Shirinbak, 14.30 uur and Mr. H. Maazi, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Immune regulation by allergen immunotherapy. Lessons learned from experimental approaches

Promotor(s): prof. A.J.M. van Oosterhout

Faculty: Medical Sciences

In this PhD thesis we aimed to unravel the mechanism of action of SIT at cellular level on the one hand and find ways to improve the efficacy of SIT in the other hand in a mouse model of allergic asthma. We found that while FOXP3+ regulatory T cells play a role in SIT-induced suppression of airway eosinophilia, CD8+ T cells, B cells and plasmacytoid dendritic cells play dispensable roles in SIT-induced suppression of airway hyperreactivity, airway eosinophilia and allergen-specific IgE levels in the serum.