Skip to ContentSkip to Navigation
About us Latest news News News articles

Galectins, (re)myelination and multiple sclerosis pathology

28 March 2012

PhD ceremony: Ms. M. Stancic, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Galectins, (re)myelination and multiple sclerosis pathology

Promotor(s): prof. D. Hoekstra

Faculty: Medical Sciences

Identification of environmental signals that regulate the behaviour of oligodendrocytes (OLG), i.e., cells that produce insulating myelin sheaths around axons, and corresponding receptors on the cell surface through which these signals act, is necessary to understand both normal OLG development and their behaviour in demyelinating diseases, such as multiple sclerosis (MS). The findings in this thesis point to a role of galectins, i.e., β-galactoside-binding proteins, in the interaction between cells of the central nervous system that are likely highly relevant to myelination and demyelination of axons. The discovery of galactin-4 as a novel neuronal regulator of the timing of myelination will add to an improved understanding of mechanisms of (re)myelination. A misbalance in galectin-4 expression and its release from neurons or the interaction of galectin-4 with different components of the extracellular matrix might be responsible for remyelination failure in MS. Roles of galectins-1, -2, -3, -4 and -8 in the regulation of glial cell viability, survival and proliferation are also described. Interestingly, expression of some of these galectins is upregulated in MS lesions, and evidence suggests that they are of potential importance for the pathological mechanisms underlying MS. Taken together, the studies presented in this thesis warrant further research on galectins as promising targets for MS treatment since they are both potent regulators of inflammatory processes and glia cell behaviour.

Last modified:13 March 2020 12.59 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...