Novel asymmetric copper-catalyzed transformations

PhD ceremony: Mr. P.H. Bos, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Novel asymmetric copper-catalyzed transformations

Promotor(s): prof. B.L. Feringa

Faculty: Mathematics and Natural Sciences

As a consequence of the increased complexity of target molecules both in industry and academic research, the development of new methodology remains an important aspect of organic chemistry both in current time as well as for the future. Across the entire field of chemistry, from material science to pharmaceutical chemistry, efficient synthetic methods are crucial and of increasing importance, especially in the context of sustainable chemistry for the future. This thesis describes the development of a variety of novel asymmetric carbon-carbon bond forming reactions. All of the methods that were developed in this thesis rely on the use of catalytic amounts of chiral copper/ligand complexes in combination with organometallic reagents to establish asymmetric carbon-carbon bond formation with excellent enantiomeric excess.