PhD ceremony: Mr. S. Vegter, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: The value of personalized approaches to improve pharmacotherapy in renal disease
Promotor(s): prof. M.J. Postma, prof. G. Navis
Faculty: Mathematics and Natural Sciences
Renal diseases decrease patients’ life expectancy and quality of life and strain health-care budgets. In the quest to improve pharmacotherapy, personalized approaches tailored for individual patients are increasing in importance. Work presented in the thesis of Stefan Vegter includes a checklist for health technology assessment of genetic screen-and-treat strategies; and explored two such strategies in renal medicine. It was found that the ACE (I/D) polymorphism influences the (cost-)effectiveness of ACE inhibitors in non-diabetic renal disease. The second genetic strategy involved a polymorphism coding for the CCR5 receptor, the genetic deficiency of which is associated with improved survival in dialysis patients. A modelling study in this study suggested that pharmacologic blockade of the CCR5 receptor has similar potential for clinical and economic benefits. Vegters thesis also deals with non-genetic approaches to improve pharmacotherapy. Firstly, optimal prescribing strategies may result in economic benefits, as studied in his thesis for specific phosphate binders (lanthanum carbonate) used as second-line therapy. Evidence was also presented favouring cheap RAAS intervening drugs, as no difference in therapy compliance was found between cheap and more expensive drugs. Secondly, pharmacotherapy can be improved by correctly diagnosing and treating adverse side effects, as studied in this thesis for ACE inhibitor induced cough. Thirdly, therapy effectiveness of ACE inhibitors can be improved for patients eating too much salt; lower salt intake was associated with decreased renal disease progression. In conclusion, personalized approaches to improve pharmacotherapy in renal disease may improve the individual patients’ health and quality of life, and may also decrease the economic disease burden for society.
Three researchers of the Faculty of Science and Engineering have been awarded an ENW-XS grant by the Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijke Onderzoek, NWO): Prof. A.I. Guskov the Groningen Biomolecular Sciences and...
Bayu Jayawardhana has been appointed scientific director of DISC, the interuniversity research institute and graduate school that unites all university groups in the Netherlands that are active in systems and control theory and engineering. The...
Researchers Clemens Mayer and Danny Incarnato of the University of Groningen have been awarded an ERC Consolidator Grant.
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