Molecular unraveling of interspecies crosstalk
PhD ceremony: Ms. L.M. Jarosz, 14.30 uur, Aula Academiegebouw, Broerstraat 5, Groningen
Dissertation: Molecular unraveling of interspecies crosstalk
Promotor(s): prof. H.C. van der Mei
Faculty: Medical Sciences
Interspecies cross-talk is an attractive subject for many researchers due to its fundamental nature but also the clinical relevance. In this thesis we studied some aspects of interspecies communication between eukarya and prokarya. We focused on Candida albicans as a representative of eukarya, communicating with various Gram-positive and Gram-negative bacteria, each using a range of structurally distinct signaling molecules. This thesis contains two parts; in the first chapters we described the development of an assay to study the effect of bacterial small molecules on C. albicans hypha formation, and identification of two additional small bacterial quorum sensing (QS) molecules that affect hypha formation. In the second part we described development and validation in different species (Pseudomonas aeruginosa, C. albicans and Staphylococcus aureus) of a newly designed methodology using a biomimetic molecule that can be used to identify the receptors for QS molecules.
Last modified: | 13 March 2020 12.59 a.m. |
More news
-
29 November 2023
UMCG opent nieuwe faciliteit voor microbioomonderzoek 
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
-
28 November 2023
Science: more exciting than showbiz
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
-
13 November 2023
UMCG beantwoordt vragen patiënten met hulp van AI
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...