Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Treatment impact on the intestinal microbiota

23 November 2011

PhD ceremony: Mr. R.F.J. Benus, 11.00 uur, Aula Academiegebouw, Broerstraat 5, Groningen

Dissertation: Treatment impact on the intestinal microbiota

Promotor(s): prof. T.S. van der Werf, prof. J.E. Degener

Faculty: Medical Sciences

This thesis describes the effects of antibiotics and tube feeding on our protective intestinal microbiota. Antibiotics are administered to patients in the intensive care unit (ICU) through Selective Digestive Decontamination (SDD) to prevent infections by harmful intestinal bacteria. It was found that suppressing bacteria in the mouth and throat only, i.e., Selective Oropharyngeal Decontamination (SOD), may be as helpful. SDD and SOD were effective in reducing mortality. It was shown that SDD, unlike SOD, severely suppresses certain groups of beneficial bacteria, especially F. prausnitzii. These bacteria produce butyrate which is essential for a healthy intestinal mucosa. ICU patients not only receive antibiotics but also tube feeding. The effects of enteral feeding with or without dietary fiber on the intestinal microbiota were studied. The addition of certain dietary fibers showed a significant effect on these healthy bacteria. Another mechanism that was studied is the suppression of butyrate-producing bacteria. F. prausnitzii appears to be susceptible to many antibiotics. During SDD, a group of bacteria in the gut, enterococci, increases. These are usually relatively harmless, although among patients in the UMCG serious enterococcal infections appear to occur regularly, as evidenced by an exploratory study in which only the bloodstream infections were considered. There was no noticeable effect of the SDD research on the incidence of these infections.

Last modified:15 September 2017 3.40 p.m.
printView this page in: Nederlands

More news

  • 11 July 2019

    Major companies’ annual reports too vague about climate impact

    Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...

  • 08 July 2019

    Zeven RUG-projecten krijgen financiering via de NWA Ideeëngenerator

    De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...

  • 08 July 2019

    UG permanently closes Yantai project

    The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.