Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Vasoregression in incipient diabetic retinopathy. Angiopoietin-2 dependency and the effect of erythropoietin and carnosine treatment

10 October 2011

PhD ceremony: Mr. F. Pfister, 16.15 uur, Aula Academiegebouw, Broerstraat 5, Groningen

Dissertat: Vasoregression in incipient diabetic retinopathy. Angiopoietin-2 dependency and the effect of erythropoietin and carnosine treatment

Promotor(s): prof. G. Molema, prof. H.-P. Hammes

Faculty: Medical Sciences

The initial vascular changes of diabetic retinopathy (DR) are loss of capillary pericytes and vasoregression. The mechanisms causing diabetic vasoregression are complex and not completely understood. Recent findings indicated the importance of Ang-2 in DR, which was the subject of this thesis. The data show that overexpression of Ang-2 impairs pericyte recruitment and thereby enhances angiogenesis under physiological and pathological conditions. In diabetic and aging retinas, Ang-2 induces loss of retinal pericytes and vasoregression and we identified a new Ang-2 dependent mechanism of diabetic pericyte loss. The results described in this thesis indicate that the initiation and propagation of diabetic retinopathy strongly depends on firm pericyte coverage and the complex interplay between survival factors, such as VEGF, Hsp and other growth factors like the angiopoietins. Furthermore, we show that the neuroglial retina is a major target of early hyperglycemic damage and a key component in the pathogenesis of incipient DR. Understanding the interaction between neuroglial and vascular cells and the importance of factors released by these cells is of utmost importance for the development of novel and specific molecular drug targets with the potential to prevent or arrest the progression of DR.

Last modified:15 September 2017 3.41 p.m.

More news

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...

  • 02 April 2019

    UMCG onderzoekt behandeling tegen geheugenachteruitgang ouderen

    Is het mogelijk om achteruitgang van geheugen en denkvermogen bij ouderen te remmen door hun hersenen letterlijk actiever te maken? Kan stimulatie met zwakke stroompjes op de schedel de veerkracht van hersenen versterken? Hersenonderzoekers van het...