Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Lamotrigine in bipolar depression. A randomised placebo-controlled trial on the acute and long-term outcome of lamotrigine as add-on to lithium with the possibility of the addition of paroxetine

28 September 2011

PhD ceremony: Mr. M.L.M. van der Loos, 11.00 uur, Aula Academiegebouw, Broerstraat 5, Groningen

Dissertation: Lamotrigine in bipolar depression. A randomised placebo-controlled trial on the acute and long-term outcome of lamotrigine as add-on to lithium with the possibility of the addition of paroxetine

Promotor(s): prof. W.A. Nolen

Faculty: Medical Sciences

Patients with bipolar disease (also known as manic depression) who are treated with lithium, may benefit from the addition of the antiepileptic drug lamotrigine during the depressive stage of their disease. Van der Loos performed a randomised controlled clinical trial in which he compared the addition of lamotrigine with placebo as add-on to lithium. The outcomes of patients using lamotrigine were significantly better than for those on placebo. Patients who did not respond to treatment received paroxetine after 8 weeks. Both groups improved further, but after 16 weeks the results were not statistically different anymore. Also during the long-term phase of the study, the differences between responders on study treatment and placebo remained stable.

Last modified:15 September 2017 3.40 p.m.

More news

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...

  • 02 April 2019

    UMCG onderzoekt behandeling tegen geheugenachteruitgang ouderen

    Is het mogelijk om achteruitgang van geheugen en denkvermogen bij ouderen te remmen door hun hersenen letterlijk actiever te maken? Kan stimulatie met zwakke stroompjes op de schedel de veerkracht van hersenen versterken? Hersenonderzoekers van het...