PhD ceremony: Mr. S. van Assen, 16.15 uur, Aula Academiegebouw, Broerstraat 5, Groningen
Dissertation: Influenza vaccination in primary and secondary immunodeficiencies
Promotor(s): prof. C.G.M. Kallenberg
Faculty: Medical Sciences
Patients with immunodeficiencies are at increased risk of contracting common and/or opportunistic infections, that might be prevented or mitigated by vaccination. We investigated the humoral and cell-mediated immune (CMI) responses following influenza vaccination in patients with humoral primary immunodeficiencies (hPID), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)-patients treated with rituximab. In patients with hPID humoral responses following influenza vaccination were clearly hampered. Previous vaccination and treatment with intravenous immunoglobulin did not result in higher seroprotection rates. Antibody responses were also decreased in SLE-patients. A second influenza vaccination four weeks later only led to an additional increase in the influenza-specific antibody responses in not previously vaccinated SLE-patients. Influenza vaccination within four to eight weeks after administration of rituximab did not result in a humoral response in rituximab-induced B-cell depleted RA-patients. Six to 10 months following rituximab therapy an antibody response was found although it was still hampered. CMI responses following influenza vaccination were impaired in the hPID, SLE and rituximab-treated RA-patients. In SLE-patients reduced CMI responses were associated with the use of prednisone and/or azathioprine. In conclusion, the patients with primary and secondary immunodeficiencies we investigated demonstrated hampered humoral and CMI responses following influenza vaccination. We developed evidence- and expert-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseases for the European League Against Rheumatism (EULAR).
Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...
De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...
The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.