Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Strategies to improve the outcome of biliary atresia – lessons from the Dutch national database

14 September 2011

PhD ceremony: Ms. W. de Vries, 14.45 uur, Aula Academiegebouw, Broerstraat 5, Groningen

Dissertation: Strategies to improve the outcome of biliary atresia – lessons from the Dutch national database

Promotor(s): prof. H.J. Verkade

Faculty: Medical Sciences

 

Biliary atresia (BA) is a severe but rare liver disease of infancy (1:18,000 life births), characterized by complete fibrotic obliteration of the bile ducts and cholestasis, with unknown cause. Treatment is surgical via Kasai’s porto-enterostomy. This technique results in longstanding biliary drainage in 25% of the patients. In the remaining group of patients, liver damage continues and sooner or later a liver transplantation will be necessary.

Using the Dutch national BA patient database, De Vries searched for strategies to improve treatment outcome of BA patients. The pre-transplant mortality appeared to be relatively high in the Netherlands. Referral for liver transplantation in a too advanced state of disease appeared to be an important factor. She also found strong suggestions that early Kasai surgery (before the age of 60 days) and the use of post-Kasai antibiotic prophylaxis may increase the transplant-free survival. In addition, post-Kasai BA patients who have reached adulthood were studied. One fifth of all BA patients survives into adulthood without signs of liver cirrhosis. Furthermore, De Vries studied the health-related quality of life in adult BA patients and the achievement of developmental milestones into adulthood.

 

Last modified:15 September 2017 3.40 p.m.

More news

  • 23 April 2019

    From paperclip to patent

    How is it possible that an albatross doesn’t crash and die when it lands? And how come its large wings don’t break due to air resistance? That is what you would expect, according to the laws of aerodynamics. However, Professor Eize Stamhuis has discovered...

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...