The polycomb gene BMI1 in normal hematopoiesis and leukemia

PhD ceremony: Ms. A. Rizo, 16.15 uur, Doopsgezinde kerk, Oude Boteringestraat 33, Groningen

Dissertation: The polycomb gene BMI1 in normal hematopoiesis and leukemia

Promotor(s): prof. G. de Haan, prof. J.J. Schuringa, prof. E. Vellenga

Faculty: Medical Sciences

In this thesis we aimed to obtain further insight into the role of the gene BMI1 one of the possible regulators of hematopoiesis. We studied its role in normal human hematopoietic stem cells as well as in mechanisms by which it may contribute to leukemic transformation.