Skip to ContentSkip to Navigation
About us Latest news News News articles

Personalized pharmacotherapy of psychosis clinical and pharmacogenetic approaches

08 June 2011

PhD ceremony: Mr. J. Vehof, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Personalized pharmacotherapy of psychosis clinical and pharmacogenetic approaches

Promotor(s): prof. H. Snieder, prof. R.P. Stolk

Faculty: Medical Sciences


Despite 60 years of antipsychotic drugs, the pharmacotherapy of psychosis is still far from ideal. In particular side-effects, such as weight gain and therapy induced movement disorders, are major problems. The aim of this thesis is to contribute to the development of personalised medicine for the treatment of psychosis through the study of clinical factors in the use of oral and depot antipsychotic drugs, and the pharmacogenetics of antipsychotic response and drug-induced side effects. Several clinical factors were determined that predict which patients switch form oral to depot treatment, including the presence of movement disorders, lack of compliance, and lack of psychiatric co-morbidity. New associations were found between various polymorphisms in receptor genes and metabolic disturbances and movement disorders in patients on antipsychotic medication. The researchers were not able to replicate several associations of polymorphisms that were found in earlier studies. Negative results and lack of replication are common in pharmcogenetic studies of antipsychotic drugs. There is growing evidence that environmental, ethnic and many other factors affect the link between genetic variation and the efficacy of antipsychotic drugs.


Last modified:13 March 2020 01.12 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...