Skip to ContentSkip to Navigation
About us Latest news News News articles

The role of heat shock proteins in PolyQ disorders

30 May 2011

PhD ceremony: Ms. M.P. Zijlstra, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: The role of heat shock proteins in PolyQ disorders

Promotor(s): prof. H.H. Kampinga, prof. O.C.M. Sibon

Faculty: Medical Sciences

 

Some neurodegenerative diseases are the result of aggregation of damaged proteins in cells of the central nervous system. Huntington’s disease is a well-known example. The focus of this thesis was to study the role of heat shock proteins in protein quality control routes in relation to the progression of neurodegenerative diseases. Various types of heat shock proteins were found with different effects on protein aggregation. A heat shock protein with activity on autophagy, the bulk degradation system of the cell, was identified as the strongest suppressor of protein aggregation in the neurodegenerative diseases under study. Experiments with heat shock proteins in model systems indicated possibilities for reducing progression in neurodegenerative diseases.

 

Last modified:13 March 2020 01.12 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...