Skip to ContentSkip to Navigation
About us Latest news News News articles

In vivo estimation of gluconeogenesis

25 May 2011

PhD ceremony: Mr. S.K. Chacko, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen

Title: In vivo estimation of gluconeogenesis

Promotor(s): prof. P.J.J. Sauer, prof. A.L. Sunehag

Faculty: Medical Sciences


Detailed knowledge about glucose kinetics is crucial to understand metabolic diseases and to optimize nutritional strategies. As a part of this thesis, we developed a simple, accurate and reproducible method based on mass spectroscopy to estimate in vivo rates of gluconeogenesis in different populations under various conditions to address a variety of metabolic issues.

The estimation of gluconeogenesis using the newly developed method enabled us to determine that gluconeogenesis accounts for the major part of glucose production and is an ongoing process in preterm infants even when glucose is supplied at rates exceeding their normal glucose turnover rate. We also reported that the incomplete suppression of glucose production observed in preterm infants is primarily due to the contribution from gluconeogenesis. Further, our investigations determined that gluconeogenesis is not acutely regulated by either insulin or glucose concentrations in very preterm infants receiving total parenteral nutrition.

These findings are crucial to optimize nutritional strategies in premature infants. The results suggest that supplying glucose at rates corresponding to normal infant glucose turnover rate (in addition to glucose produced via gluconeogenesis utilizing the supplied gluconegenic substrates via TPN) is a potential strategy to prevent hypo/hyperglycemia in infants during their early days of life.

In this thesis we also reported that the extra glucose demands of lactation during the extended periods of fasting in lactating women are met by increasing gluconeogenesis. Further investigations of this thesis using a mice model determined that ghrelin plays a role in the regulation of gluconeogenesis/glycogenolysis and that the absence of ghrelin action has a beneficial outcome on glucose metabolism.


Last modified:13 March 2020 01.10 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...