Molecular markers for diagnosis and prognosis in cervical neoplasia
PhD ceremony: Mr. J.J.H. Eijsink, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Molecular markers for diagnosis and prognosis in cervical neoplasia
Promotor(s): prof. A.G.J. van der Zee, prof. H. Hollema, prof. G.H. de Bock
Faculty: Medical Sciences
Population-based screening has reduced the incidence of cervical cancer significantly in Western countries, but there is still room for improvement. A test based on detection of DNA methylation appears to be an attractive tool for cervical neoplasia screening because gene promoter methylation marks an early event in cervical carcinogenesis. In this thesis a methylation test for cervical cancer using four methylation markers was developed and evaluated. The test has the potential to detect 95% of cervical cancers and 65% of high-grade premalignant lesions. It was also shown that the methylation test is feasible on cervico-vaginal lavages obtained by a self-sampling device. A self-sampling approach may be a useful alternative screening strategy because 30% of the Dutch women do not attend the screening programme, and almost half of the cervical cancer patients are diagnosed in this population.
Last modified: | 13 March 2020 01.10 a.m. |
More news
-
29 November 2023
UMCG opent nieuwe faciliteit voor microbioomonderzoek 
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
-
28 November 2023
Science: more exciting than showbiz
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
-
13 November 2023
UMCG beantwoordt vragen patiënten met hulp van AI
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...