PhD ceremony: Mr. B.M. Tesson, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Genetical genomics approaches for systems genetics
Promotor(s): prof. R.C. Jansen, prof. R. Breitling
Faculty: Mathematics and Natural Sciences
Variation in DNA sequences is at the source of much phenotypic diversity. Understanding the biological mechanisms through which this variation affects tissues, organs or organisms is the aim of systems genetics. Genetical genomics uses quantitative genetics approaches to identify the naturally occurring allelic variants responsible for differential abundance of molecular traits such as messenger RNAs, proteins or metabolites. The thesisof Bruno Tesson explores the potential of genetical genomics to dissect the molecular interplay that gives rise to complex phenotypes (e.g. diseases) and thereby, contribute to the larger ambition of systems genetics.
The different steps of a genetical genomics study are detailed by Tesson, with such an analysis performed on transcriptomic data from mouse hematopoietic cells. The results demonstrate that the effects of natural DNA variation on gene expression are highly sensitive to cell differentiation stage, emphasizing the need for cellular targeting in systems genetics. A careful permutation strategy is advocated to guard against erroneous interpretation of expression quantitative trait loci (eQTL) hotspots as major genetic regulators.
Also a novel method is proposed by Tesson to study differential coexpression, offering complementary insights to classical differential expression analysis. Elucidating the role of individual genes, proteins or metabolites in the acquisition of specific phenotypes requires the ability to infer causal relationships between those traits. The potential and limitations of existing causal inference methods in genetical genomics is explored. Finally, current and future systems genetics challenges arising in experimental design, statistical significance and network reconstruction are discussed by him.
Three researchers of the Faculty of Science and Engineering have been awarded an ENW-XS grant by the Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijke Onderzoek, NWO): Prof. A.I. Guskov the Groningen Biomolecular Sciences and...
Bayu Jayawardhana has been appointed scientific director of DISC, the interuniversity research institute and graduate school that unites all university groups in the Netherlands that are active in systems and control theory and engineering. The...
Researchers Clemens Mayer and Danny Incarnato of the University of Groningen have been awarded an ERC Consolidator Grant.
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