Skip to ContentSkip to Navigation
About us Latest news News News articles

Physical activity and obesity-related metabolic impairments: estimating interation from an additive model

11 May 2011

PhD ceremony: Ms. L. Qin, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Physical activity and obesity-related metabolic impairments: estimating interation from an additive model

Promotor(s): prof. R.P. Stolk

Faculty: Medical Sciences

 

Increased physical activity is associated with a reduced risk of type 2 diabetes. However, physical activity is also the key to treat adiposity, and it therefore may modify the association between adiposity and diabetes. It is unclear whether “fatfit” or “lean-unfit” individuals have an increased diabetes risk, and whether obese individuals could benefit from increased physical activity independent of the changes in body composition.

The main objective of this thesis was to investigate whether physical activity interacts with adiposity in relation to diabetes. We reviewed the epidemiological evidence of the joint effect of obesity and physical inactivity, to discern the additive and multiplicative interactions. The results indicate that increased body weight is a stronger diabetes risk factor than physical inactivity, and that these show additive interaction.

Second, the joint effect of these two factors with fasting glucose was examined in the Guangzhou Biobank Cohort Study (n=28,946). The risk reduction of diabetes due to this combined effect was further quantified in the Finnish Diabetes Prevention Study (n=487), a lifestyle intervention trial. Both studies confirmed the interactive effects. Moreover, we extensively investigated the influence of biological background (like ethnicity, aging), hyperglycemia, the intensity of physical activity, and the different adiposity indices.

Finally, we also investigated several methodological issues involved in etiologic epidemiological research (like interaction models, confounding, mediating, and measurement errors), and the links between pathophysiology, epidemiology and clinical implications.

Last modified:13 March 2020 01.12 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...