Skip to ContentSkip to Navigation
About usNews and EventsNews articles

TRAIL-receptor and proteasome targeted therapies in non-small cell lung cancer

20 April 2011

PhD ceremony: Ms. J.H. Stegehuis, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: TRAIL-receptor and proteasome targeted therapies in non-small cell lung cancer

Promotor(s): prof. E.G.E. de Vries

Faculty: Medical Sciences

 

The natural occurring protein TRAIL is important in the battle against cancer. TRAIL binds to healthy cells where it but does not cause damage, whereas binding to tumour cells may lead to their elimination. Various TRAIL-receptor targeting drugs are likely to increase the activity of anticancer drugs, as has been shown in preclinical studies. The aim of this thesis was to explore the combined use of TRAIL-receptor targeting therapies with the anticancer drug bortezomib in preclinical models of non-small cell lung cancer. It was found that the combination strongly induces apoptosis. Bortezomib could overcome tumour cell preferences for TRAIL-receptor1 or TRAIL-receptor2 apoptosis and enhance apoptosis induced via both receptors in the cancer cells. Examination of the underlying mechanisms revealed that bortezomib could sensitize TRAIL-induced apoptosis at the level of DISC (at the membrane) as well as at the level of the mitochondria (intracellular). Bortezomib had an effect on TRAIL-receptor endocytosis, although its functionality remains unknown.

 

Last modified:15 September 2017 3.40 p.m.

More news

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...

  • 02 April 2019

    UMCG onderzoekt behandeling tegen geheugenachteruitgang ouderen

    Is het mogelijk om achteruitgang van geheugen en denkvermogen bij ouderen te remmen door hun hersenen letterlijk actiever te maken? Kan stimulatie met zwakke stroompjes op de schedel de veerkracht van hersenen versterken? Hersenonderzoekers van het...