Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Improved dissolution behavior of lipophilic drugs by solid dispersions: a matter of composition

18 April 2011

PhD ceremony: Ms. P. Srinarong, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Improved dissolution behavior of lipophilic drugs by solid dispersions: a matter of composition

Promotor(s): prof. H.W. Frijlink

Faculty: Mathematics and Natural Sciences

 

Solid dispersions can be used to improve the dissolution behavior of poorly water-soluble drugs and thereby their bioavailability after oral administration. Solid dispersions are generally composed of drugs incorporated in hydrophilic carriers. Parinda Srinarong has investigated the effects of the type and molecular weight of the hydrophilic carrier, the drug load and the presence of additives on the dissolution behavior and stability of tablets prepared from solid dispersions were.

It was found by her that when the drug load was high and/or when the carrier dissolved fast, the dissolution rate of the drug was slow. This phenomenon was attributed to uncontrolled crystallization of the drug in the near vicinity of the dissolving tablet due to a high supersaturation. Higher drug loads could be applied without the occurrence of recrystallization of the drug when carriers were used that interacted with the drugs. This could Srinarong ascribe to an increased solubility of the drug in the near vicinity of the dissolving tablet due to a high local concentration of the carrier. Furthermore, it was found by her that the incorporation of a superdisintegrant in the solid dispersion tablets can also prevent recrystallization of the drug. In this case, the tablet disintegrated so fast that supersaturation of the drug in the near vicinity of the dissolving tablet was prevented. To demonstrate the potential of this platform technology, it was applied to a range of different drugs such as diazepam, fenofibrate, ritonavir, efavirenz and tacrolimus.

Finally, a number of the solid dispersion tablets that showed excellent dissolution behavior also showed an excellent storage stability.

 

Last modified:15 September 2017 3.40 p.m.

More news

  • 23 April 2019

    From paperclip to patent

    How is it possible that an albatross doesn’t crash and die when it lands? And how come its large wings don’t break due to air resistance? That is what you would expect, according to the laws of aerodynamics. However, Professor Eize Stamhuis has discovered...

  • 17 April 2019

    Why lightning often strikes twice

    In contrast to popular belief, lightning often does strike twice, but the reason why a lightning channel is ‘reused’ has remained a mystery. Now, an international research team led by the University of Groningen has used the LOFAR radio telescope to...

  • 16 April 2019

    Still going strong after four decades

    On March 29th professor of Applied Physics Jeff de Hosson was offered a farewell symposium, a few months after his official retirement date near the close of 2018. ‘But 29 March was the 100th birthday of Jan Francken, my predecessor.’ Besides, De Hosson...