Small regulatory RNAs: identification, classification and utilization
PhD ceremony: Mr. E. Seinen, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Small regulatory RNAs: identification, classification and utilization
Promotor(s): prof. O.C.M. Sibon, prof. R.C. Jansen
Faculty: Medical Sciences
An important field of research in the life sciences is to investigate the function of genes, which is typically performed with RNA interference (RNAi) technology. Through RNAi it is possible to down regulate specific genes. Unfortunately, RNAi is hampered by so called “off-targets” that induce down regulation of non-related genes. Using a novel method to find off-targets, it was demonstrated that some RNAi molecules show a substantial number of off-targets which may lead to an incorrect interpretation of experimental data. It was also found that current methods to avoid off-targets have significant flaws. Seinen developed a new computer program, RNAi-Select, to reduce off-targets by analysing genomic sequences with high precision and to utilise these data to design unique RNAi molecules. The computer program can assist in the identification of endogenous miRNAs which are associated with diseases such as PKAN and Hodgkin’s lymphoma.
Last modified: | 13 March 2020 01.11 a.m. |
More news
-
29 November 2023
UMCG opent nieuwe faciliteit voor microbioomonderzoek 
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
-
28 November 2023
Science: more exciting than showbiz
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
-
13 November 2023
UMCG beantwoordt vragen patiënten met hulp van AI
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...