Skip to ContentSkip to Navigation
About usNews and EventsNews articles

The expanding world of RAAS: novel insights in the development of renal disease

04 April 2011

PhD ceremony: Ms. J. Kamilic, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Title: The expanding world of RAAS: novel insights in the development of renal disease

Promotor(s): prof. H. van Goor, prof. G.J. Navis

Faculty: Medical Sciences


Every year the number of people with chronic renal disease increases. Despite the available treatment options, many patients reach the point where they need dialysis or kidney transplant. These treatments are necessary, but at the same time form a heavy burden for the patient and society. Researcher Jelena Kamilic investigated causes of renal disease. She focused on the renin-angiotensin aldosterone system (RAAS) which is the most important hormonal system for the regulation of blood pressure, sodium balance and extracellular blood volume. A good regulation of RAAS is central to limiting progress in kidney disease.In an animal model it was shown that genetic polymorphism (WU-L and WU-B) determine different levels of damage following stimulation with angiotensin II. These results are promising, because this type of genetic diversity is also present in humans. Furthermore, it was found that DNA methylation status was associated with the level of tubulointestinal damage.



Last modified:15 September 2017 3.40 p.m.

More news

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...

  • 02 April 2019

    UMCG onderzoekt behandeling tegen geheugenachteruitgang ouderen

    Is het mogelijk om achteruitgang van geheugen en denkvermogen bij ouderen te remmen door hun hersenen letterlijk actiever te maken? Kan stimulatie met zwakke stroompjes op de schedel de veerkracht van hersenen versterken? Hersenonderzoekers van het...