Skip to ContentSkip to Navigation
About us Latest news News News articles

Unusual variants of subepidermal autoimmune bullous diseases

30 March 2011

PhD ceremony: Ms. J.J.A. Buijsrogge, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Unusual variants of subepidermal autoimmune bullous diseases

Promotor(s): prof. M.F. Jonkman

Faculty: Medical Sciences


Subepidermal acquired immunobullous diseases (sAIBD) are characterised by blisters that develop in skin and mucous membranes, for example in the mouth. Although it is well-known that these diseases are the result of a degradation of the immune system, their specific mechanisms are not well understood. Jacqueline Buijsrogge performed her PhD research at the Department of Dermatology of the University Medical Center Groningen.

The autoantibody plectine was found to play a possible role in the development of pemphigoid, a common form of sAIBD. The protein BP180 likely plays a role in oral lichen planus (OLP), a chronic inflammatory disease in the mouth. These findings are considered a connecting element between pemphigoid and OLP. Furthermore it was found that clinical recognition and the utilization of diagnostic methods largely influence the diagnosis of sAIBD. For example, if only serum diagnostics are performed without also studying skin biopsies, two out of three patients with EBA will not be diagnosed.

Last modified:13 March 2020 01.09 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...