PhD ceremony: Mr. Falak Sher, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Differentiation of neural stem cells into oligodendrocytes. Epigenetic mechanisms & potential applications in multiple sclerosis
Promotor(s): prof. H.W.G.M. Boddeke
Faculty: Medical Sciences
Differentiation of neural stem cells into oligodendrocytes, the myelinating brain cells, is a potential source for grafting to restore axonal damage in multiple sclerosis. The research focused on (a) revealing regulatory mechanisms that underlie the differentiation of neural stem cells into oligodendrocyte precursor cells, and (b) monitoring the survival, migration, and functionality of these oligodendrocyte precursor cells after implantation in multiple sclerosis animal models. An epigenetic regulator protein was identified as indispensable factor for stable differentiation of neural stem cells. Also, the researchers located the specific genes whose expression is controlled during neural stem cell differentiation. After grafting the oligodendrocyte precursor cells, the long-term ability to remyelinate axons and their efficacy to reduce clinical symptoms in acute and chronic episodes of multiple sclerosis was demonstrated.
Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...
De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...
The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.