PhD ceremony: Mr. A.P.J. Vries, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Risk factors for late graft failure and mortality in renal transplantation
Promotor(s): prof. R.O.B. Gans, prof. W.J. van Son
Faculty: Medical Sciences
Despite all improvements in transplant medicine, renal transplant patients have a high risk for cardiovascular mortality. A measure of heart failure, impaired renal allograft function, and antihypertensive medication, explained the excess risk for cardiovascular mortality to a greater extent than the presence of the metabolic syndrome.
A year after the transplantation, a majority of renal transplant recipients had developed the metabolic syndrome which is a risk factor for cardiovascular disease. The metabolic syndrome was defined as a complex of overweight or obesity, high blood pressure and an unfavourable profile of cholesterol variables. The metabolic syndrome is associated with impaired renal allograft function and increased insulin resistance.
Women suffered more often from post-transplant weight gain and metabolic syndrome than men. Overweight, in particular central obesity, and the immunosuppressant prednisolon were found as most important determinants of insulin resistance. Renal transplant recipients had a 6 to 7 times higher risk of premature mortality as compared to matched controls in the general population. A measure of heart failure, impaired renal allograft function, and antihypertensive medication, explained the cardiovascular risk factors more than the presence of the metabolic syndrome.
How is it possible that an albatross doesn’t crash and die when it lands? And how come its large wings don’t break due to air resistance? That is what you would expect, according to the laws of aerodynamics. However, Professor Eize Stamhuis has discovered...
Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...
‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...