PhD ceremony: Ms. A.K. Krabbe Lugnér, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Cost-effectiveness of controlling infectious diseases from a public health perspective
Promoter(s): prof. M.J. Postma
Faculty: Mathematics and Natural Sciences
In her thesis Anna Krabbe Lugnér investigated the cost-effectiveness of public health interventions in the Netherlands against three specific infectious diseases: pandemic influenza, rubella and pertussis. She developed a dynamic transmission model for the pandemic influenza preparedness planning and applied to possible interventions during a pandemic that could cause a high number of infections and deaths. Her results showed that both vaccination and treatment with antiviral drugs were cost-effective when targeted at reducing the transmission and the complications of illness. The cost-effectiveness of stockpiling antiviral drugs to use during a pandemic depended heavily on the probability of a pandemic outbreak. In comparing the cost-effectiveness of different vaccination strategies, it was shown by Krabbe Lugnér that already existing immunity among elderly affects the cost-effectiveness and changes the preferred strategy, partly due to the reduced transmission. The importance of external effects of vaccination was shown, entailing protection of non-vaccinated individuals due to less circulation and transmission of an infection. In regions with a low-vaccination-rate, outbreaks of vaccine-preventable infectious diseases, such as rubella, can cause considerable illness. Krabbe Lugnér has also investigated the cost-effectiveness of a screening and vaccination program against rubella. In low-vaccination-rate regions, this program could be a cost-effective means to prevent complications in unborn babies. The final example was an economic evaluation of a pertussis-booster vaccination in four-year-olds. This vaccination strategy was not evidently cost-effective, although it has reduced the number of pertussis infections overall. Krabbe Lugnér concludes that to validly underpin improvements of public-resource allocations, the external effects of vaccination need to be included in economic evaluations.
Three researchers of the Faculty of Science and Engineering have been awarded an ENW-XS grant by the Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijke Onderzoek, NWO): Prof. A.I. Guskov the Groningen Biomolecular Sciences and...
Bayu Jayawardhana has been appointed scientific director of DISC, the interuniversity research institute and graduate school that unites all university groups in the Netherlands that are active in systems and control theory and engineering. The...
Researchers Clemens Mayer and Danny Incarnato of the University of Groningen have been awarded an ERC Consolidator Grant.
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