Skip to ContentSkip to Navigation
About us Latest news News News articles

Cost-effectiveness of controlling infectious diseases from a public health perspective

04 February 2011

PhD ceremony: Ms. A.K. Krabbe Lugnér, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Cost-effectiveness of controlling infectious diseases from a public health perspective

Promoter(s): prof. M.J. Postma

Faculty: Mathematics and Natural Sciences


In her thesis Anna Krabbe Lugnér investigated the cost-effectiveness of public health interventions in the Netherlands against three specific infectious diseases: pandemic influenza, rubella and pertussis. She developed a dynamic transmission model for the pandemic influenza preparedness planning and applied to possible interventions during a pandemic that could cause a high number of infections and deaths. Her results showed that both vaccination and treatment with antiviral drugs were cost-effective when targeted at reducing the transmission and the complications of illness. The cost-effectiveness of stockpiling antiviral drugs to use during a pandemic depended heavily on the probability of a pandemic outbreak. In comparing the cost-effectiveness of different vaccination strategies, it was shown by Krabbe Lugnér that already existing immunity among elderly affects the cost-effectiveness and changes the preferred strategy, partly due to the reduced transmission. The importance of external effects of vaccination was shown, entailing protection of non-vaccinated individuals due to less circulation and transmission of an infection. In regions with a low-vaccination-rate, outbreaks of vaccine-preventable infectious diseases, such as rubella, can cause considerable illness. Krabbe Lugnér has also investigated the cost-effectiveness of a screening and vaccination program against rubella. In low-vaccination-rate regions, this program could be a cost-effective means to prevent complications in unborn babies. The final example was an economic evaluation of a pertussis-booster vaccination in four-year-olds. This vaccination strategy was not evidently cost-effective, although it has reduced the number of pertussis infections overall. Krabbe Lugnér concludes that to validly underpin improvements of public-resource allocations, the external effects of vaccination need to be included in economic evaluations.


Last modified:13 March 2020 01.10 a.m.
printView this page in: Nederlands

More news

  • 10 July 2020

    ENLIGHT recognized as a European University

    The ENLIGHT consortium of nine European universities, including the University of Groningen, was selected within the framework of the second call for ‘European Universities’, the European Commission's pilot program for new multilateral networks....

  • 08 July 2020

    Piekopvang in Groningen voorbereid voor internationale studenten

    Aan het einde van de zomer komen er naast veel Nederlandse studenten ook internationale studenten naar Groningen om voor kortere of langere tijd te studeren aan de Hanzehogeschool Groningen (HG) of de Rijksuniversiteit Groningen (RUG). Vanwege de...

  • 08 July 2020

    Nano-Crystal Schroedinger Cats for Detecting Gravitational Waves

    Anupam Mazumdar en Steven Hoekstra and foreign colleagues present new work suggesting that a compact nano-crystal interferometer could be used as an incredibly sensitive gravitational detector called MIMAC.