Skip to ContentSkip to Navigation
About us Latest news News News articles

Renal disease progression in autosomal dominant polycystic kidney disease. A role for vasopressin?

05 January 2011

PhD ceremony: Ms. E. Meijer, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Renal disease progression in autosomal dominant polycystic kidney disease. A role for vasopressin?

Promotor(s): prof. P.E. de Jong

Faculty: Medical Sciences


This thesis (divided into three parts) focuses on markers of disease severity in ADPKD, on a potential detrimental role of endogenous vasopressin and on the applicability of V2RA in ADPKD. Part 1 illustrates that renal function is not an appropriate marker for disease severity in an early stage of ADPKD. Renal blood flow, renal volume and NGAL (a urinary damage marker) could be measured instead. In part 2, we found indications that indeed endogenous vasopressin can have a detrimental role in causing renal damage in healthy subjects, in renal transplant recipients and in ADPKD patients. In part 3, the study design of a randomized controlled trial investigating the efficacy of V2RA in ADPKD is discussed.

Last modified:13 March 2020 01.11 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...