Fatty liver disease. Pathophysiology & assessment
PhD ceremony: Ms. M.A. Edens, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: Fatty liver disease. Pathophysiology & assessment
Promotor(s): prof. R.P. Stolk
Faculty: Medical Sciences
Continuous accumulation of lipid in the liver may result in fatty liver disease (FLD). This can cause damage, such as inflammation, cirrhosis or tumours. FLD is present in 25% to 40% of adults in Western countries. In a large population-based study it was found that FLD is strongly associated with markers for cardiovascular disease. A literature study revealed that the fatty liver overproduces many markers for cardiovascular disease. Weight reduction improves both FLD and markers for cardiovascular disease. Based on the studies in this thesis and the literature three categories of risk factors for FLD are proposed: 1) risk factors for liver fat (e.g., calorie intake, exercise), 2) risk factors for inhibited liver metabolism (e.g., alcohol, specific drugs), 3) risk factors for hepatic inflammation (e.g., hepatitis, Crohn’s disease). Finally, imaging modalities for assessment of FLD were studied. A quantitative method for ultrasonography was developed which is recommended for screening.
Last modified: | 13 March 2020 01.10 a.m. |
More news
-
29 November 2023
UMCG opent nieuwe faciliteit voor microbioomonderzoek 
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
-
28 November 2023
Science: more exciting than showbiz
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
-
13 November 2023
UMCG beantwoordt vragen patiënten met hulp van AI
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...