PhD ceremony: Mr. A. Rana, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Title: The role of impaired de novo coenzyme. A biosynthesis in pantothenate-kinase associated neurodegeneration: insight from a Drosophila model
Promotor(s): prof. O.C.M. Sibon, prof. H.H. Kampinga
Faculty: Medical Sciences
In this thesis, we characterize the fly model for PKAN (Pantothenate Kinase-Associated Neurodegeneration) and show that model fly have shorter life and brain degeneration similar to PKAN patients. We also show that adding pantethine (a naturally occurring substance) to the food of the sick fruit flies with PKAN resulted in an increased life span, increased ability to climb and that the brains of the ‘sick’ flies looked better. Pantethine also works in a PKAN model of human cells. Finally, we show that wild-type mice could tolerate high doses of pantethine. Our results indicate that pantethine can be further developed as a potential therapy for the PKAN disease.
Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...
De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...
The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.