Skip to ContentSkip to Navigation
About us Latest news News News articles

The stressed brain. Inquiry into neurobiological changes associated with stress, depression and novel antidepressant treatment

13 December 2010

PhD ceremony: Ms. G. Dagyte, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen

Title: The stressed brain. Inquiry into neurobiological changes associated with stress, depression and novel antidepressant treatment

Promotor(s): prof. P.G.M. Luiten, prof. J.A. den Boer, prof. E.A. van der Zee

Faculty: Mathematics and Natural Sciences

 

The Ph.D. thesis of Girsté Dagyte aims to dissect fundamental stress-induced alterations in the brain that might predispose to psychopathology. Moreover, it investigates neurobiological changes associated with treatment of agomelatine, a new antidepressant with an innovative pharmacological profile (agomelatine acts as a melatonin receptor agonist and serotonergic 5-HT2C receptor antagonist).

Do you recognize the symptoms of stress – tensing up, hyperventilating, rapid heart beating? These are our body’s reactions to events of danger – whether it is real or imagined. Stress can save your life and boost your productivity, but if you cannot cope with it, severe and continuous stress may harm you.

Stress and its related disorders pose a considerable threat to health in modern societies. Stressful life events promote changes in the brain that may lead to psychopathology, such as major depression. Although various remedies have been developed to treat depressive disorder, their therapeutic effects are suboptimal and the specific mechanisms of action remain obscure.

The experimental work presented in the thesis of Dagyte reveals that chronic stress is accompanied by neuronal and synaptic changes in the brain. Nonetheless, the stress effects have specific temporal dynamics and depend on the type and duration of the stress experience. Dagyte\ s results also suggest that processes of neuronal and synaptic plasticity are involved in the action mechanism of agomelatine. This information yields more general insight into mechanisms underlying the recovery from stress-related psychopathologies, and thereby may open up novel prospects for their treatment and prevention.

Last modified:13 March 2020 01.15 a.m.
View this page in: Nederlands

More news

  • 13 May 2024

    ‘The colourful cells of petals never get boring!’

    Most people will enjoy colours in nature. However, the interest of evolutionary biologist Casper van der Kooi goes much further: he studies how flowers, birds, butterflies, and beetles get their colours. He also studies how these colours are used...

  • 13 May 2024

    Trapping molecules

    In his laboratory, physicist Steven Hoekstra is building an experimental set-up made of two parts: one that produces barium fluoride molecules, and a second part that traps the molecules and brings them to an almost complete standstill so they can...

  • 07 May 2024

    Lecture with soon to be Honorary Doctor Gerrit Hiemstra on May 24

    In celebration of his honorary doctorate, FSE has invited Hiemstra to give a lecture entitled ‘Science, let's talk about it’ on the morning of 24 May