The role of STAT5 and KRAS in hematopoiesis and acute myeloid leukemia

PhD ceremony: Mr. S. Fatrai, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: The role of STAT5 and KRAS in hematopoiesis and acute myeloid leukemia

Promotor(s): prof. E. Vellenga, prof. J.J. Schuringa

Faculty: Medical Sciences

The studies in this thesis investigate the effects of STAT5 and KRAS on human hematopoietic stem cell self-renewal, differentiation, and their potential role in leukemic transformation. We show that hematopoietic stem cells, but not progenitors are the exclusive target for STAT5-induced long-term self-renewal.

In summary this thesis discusses novel mechanisms that can lead to leukemic transformation and contributes to further understanding of the role of STAT5 and KRAS in the development of acute myeloid leukemia.