Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer
PhD ceremony: Ms. B.T.F. van der Gun, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer
Promotor(s): prof. M.G. Rots, prof. L.F.M.H. de Leij
Faculty: Medical Sciences
The Epithelial Cell Adhesion Molecule (EpCAM) is a protein that is abundantly present on the surface of tumor cells of almost all carcinoma types. Inhibition of the production of this protein decreases aggressiveness of the tumor cells in some carcinoma types, for example in breast cancer. However, until now, protein production can only be reduced transiently. In this research the regulation of the gene which encodes for the EpCAM protein is studied and three methods has been developed to silence EpCAM gene expression in a permanent manner.
| Last modified: | 13 March 2020 01.15 a.m. |
More news
-
06 June 2025
India-Netherlands Hydrogen Valley Fellowship Programme announced
To coincide with World Environment Day, 5 June 2025, the Indian Department of Science and Technology and the University of Groningen yesterday announced a Hydrogen Valley Fellowship Programme Partnership, allowing talented Indian scholars working on...
-
28 May 2025
Gaan avondmensen cognitief sneller achteruit dan ochtendmensen?
Wie ’s avonds opleeft en laat naar bed gaat, heeft een grotere kans op cognitieve achteruitgang dan een ochtendmens, blijkt uit UMCG-onderzoek.
-
27 May 2025
An adventure in the brain
In the exhibition Brainstorm in the University Mueseum, Iris Sommer and two other brain researchers from Groningen explain the gut-brain connection, how it was discovered that the brain does what it does, and how games motivate you to perform...