Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells

28 June 2010

PhD ceremony: Mr. B.E. Pennarun, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells

Promotor(s): prof. J.H. Kleibeuker, prof. E.G.E. de Vries

Faculty: Medical Sciences

 

It is important to develop new therapeutic options that will contribute to the improvement of colorectal cancer treatment. Chemotherapy can induce programmed cell death (apoptosis) in cancer cells. The apoptotic pathway, which is mediated by the mitochondria, is often disrupted in therapy-resistant cancer cells. An alternate route can be used to induce apoptosis in cancer cells, by using tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to activate the so-called “death receptors “at the cell membrane. In this thesis, we investigate which chemotherapeutic agents can increase the response to TRAIL in cancer cells, and the role played by the death receptors TRAIL-R1 and TRAIL-R2 in these effects.

 

Last modified:15 September 2017 3.39 p.m.

More news

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...

  • 02 April 2019

    UMCG onderzoekt behandeling tegen geheugenachteruitgang ouderen

    Is het mogelijk om achteruitgang van geheugen en denkvermogen bij ouderen te remmen door hun hersenen letterlijk actiever te maken? Kan stimulatie met zwakke stroompjes op de schedel de veerkracht van hersenen versterken? Hersenonderzoekers van het...