PhD ceremony: Mr. J. Jin, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Artificial cofactors: a marriage of homogeneous catalysis with enzymology
Promotor(s): prof. D. B. Janssen, prof. M.W. Fraaije
Faculty: Mathematics and Natural Sciences
In the evolution of enzymes, cofactors have been incorporated into enzymes to provide diverse activities. The introduction of artificial cofactors, which can alter the activity and selectivity of enzymes, can now greatly expand the repertoire of reactions of enzymes. This thesis describes the preparation and characterization of two artificial metalloproteins based on papain and penicillin G acylase (PA) that catalyze hydrogenation reactions (chapter 2 and 3). In chapter 4 and 5, the reconstitution of two flavoenzymes, eugenol oxidase (EUGO) and vanillyl alcohol oxidase (VAO), has been investigated to help understanding the process of covalent incorporation of FAD into flavoenzymes, which we consider important for designing artificial flavins and their introduction into apo flavoenzymes.
Three researchers of the Faculty of Science and Engineering have been awarded an ENW-XS grant by the Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijke Onderzoek, NWO): Prof. A.I. Guskov the Groningen Biomolecular Sciences and...
Bayu Jayawardhana has been appointed scientific director of DISC, the interuniversity research institute and graduate school that unites all university groups in the Netherlands that are active in systems and control theory and engineering. The...
Researchers Clemens Mayer and Danny Incarnato of the University of Groningen have been awarded an ERC Consolidator Grant.
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether you want to accept
or reject other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information