PhD ceremony: Mr. J. Jin, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Artificial cofactors: a marriage of homogeneous catalysis with enzymology
Promotor(s): prof. D. B. Janssen, prof. M.W. Fraaije
Faculty: Mathematics and Natural Sciences
In the evolution of enzymes, cofactors have been incorporated into enzymes to provide diverse activities. The introduction of artificial cofactors, which can alter the activity and selectivity of enzymes, can now greatly expand the repertoire of reactions of enzymes. This thesis describes the preparation and characterization of two artificial metalloproteins based on papain and penicillin G acylase (PA) that catalyze hydrogenation reactions (chapter 2 and 3). In chapter 4 and 5, the reconstitution of two flavoenzymes, eugenol oxidase (EUGO) and vanillyl alcohol oxidase (VAO), has been investigated to help understanding the process of covalent incorporation of FAD into flavoenzymes, which we consider important for designing artificial flavins and their introduction into apo flavoenzymes.
The timing, route, and destination for godwit migration is learned rather than innate. Researchers at the University of Groningen discovered this in a daring experiment, which has been published in the latest issue of the journal Current Biology.
The grant is worth EUR 500,000, of which Avraamidou and Sburlea receive around EUR 100,000.
George Azzopardi and Guru Swaroop Bennabhaktula from the Faculty of Science and Engineering have won the Ben Feringa Impact Award 2023 for their project ‘4NSEEK; Forensic Against Sexual Exploitation of Children’. In the ‘students’ category, Nine van...
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