PhD ceremony: Mr. J. Jin, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Artificial cofactors: a marriage of homogeneous catalysis with enzymology
Promotor(s): prof. D. B. Janssen, prof. M.W. Fraaije
Faculty: Mathematics and Natural Sciences
In the evolution of enzymes, cofactors have been incorporated into enzymes to provide diverse activities. The introduction of artificial cofactors, which can alter the activity and selectivity of enzymes, can now greatly expand the repertoire of reactions of enzymes. This thesis describes the preparation and characterization of two artificial metalloproteins based on papain and penicillin G acylase (PA) that catalyze hydrogenation reactions (chapter 2 and 3). In chapter 4 and 5, the reconstitution of two flavoenzymes, eugenol oxidase (EUGO) and vanillyl alcohol oxidase (VAO), has been investigated to help understanding the process of covalent incorporation of FAD into flavoenzymes, which we consider important for designing artificial flavins and their introduction into apo flavoenzymes.
Different from previous years but still surprising, fun, healthy, and for the whole family: join Groningen’s take on this year’s national weekend of science, organized by the University of Groningen (UG) and Hanze University of Applied Sciences...
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Prof. Sijbren Otto of the Stratingh Institute for Chemistry has been awarded the James Flack Norris Award in Physical Organic Chemistry of the American Chemical Society. He receives the award for his leading contribution to establishing the field...
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