New insights in tailored treatment of gastrointestinal stromal tumours
Promotie: dhr. B. Rikhof, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: New insights in tailored treatment of gastrointestinal stromal tumours
Promotor(s): prof.dr. W.T.A. van der Graaf, prof.dr. J.A. Gietema, prof.dr. A.J.H. Suurmeijer
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl
New insights in tailored treatment of gastrointestinal stromal tumours
Gastrointestinal stromal tumours (GISTs) are tumours that arise in the muscle wall of the gastrointestinal tract. GISTs are characterized by the over-expression of the receptor KIT that is mutated in most of the tumours. These mutations promote cell division and inhibition of programmed cell death. The introduction of imatinib and sunitinib, receptor tyrosine kinase inhibitors active against KIT, has considerably improved the life expectancy of patients with metastatic GIST. However, no patients are cured with these compounds because of resistance to these drugs either initially or during a prolonged period of treatment. Therefore, new therapeutic strategies need to be developed. In this thesis, studies exploring new molecular targets for the treatment of GIST are presented.
| Last modified: | 13 March 2020 01.14 a.m. |
More news
-
13 October 2023
Moniek Tromp appointed Captain of Science of the Top Sector Chemistry
Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.
-
12 September 2023
Art in times of AI
Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...
-
28 August 2023
Harish Vedantham and Casper van der Kooi nominated for 'Wetenschapstalent 2023'
Harish Vedantham and Casper van der Kooi have been nominated by New Scientist for Wetenschapstalent 2023 (Science Talent 2023). This election is meant to give young scientists and their research a stage.