Sorting of peroxisomal flavoproteins in yeast
PhD ceremony: Ms. S.H. Klompmaker, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Sorting of peroxisomal flavoproteins in yeast
Promotor(s): Prof. I.J. van der Klei, Prof. M. Veenhuis
Faculty: Mathematics and Natural Sciences
Peroxisomes are cell organelles that are present in almost all cells of higher organisms such as animals, plants and fungi. They play an important role in various metabolic pathways like the degradation of fatty acids and hydrogen peroxide. A unique feature of peroxisomes is their ability to import folded and oligomerized matrix proteins. These proteins contain either of the two known sorting signals (designated PTS1 and PTS2), which are recognized by the soluble receptor proteins Pex5p or Pex7p respectively.
Interestingly, a subset of peroxisomal matrix proteins lacks a PTS1 or PTS2. The research described in this thesis of Sandra Klompmaker focussed on three peroxisomal matrix proteins of this group, namely acyl CoA oxidase, alcohol oxidase and D-amino acid oxidase. Her studies revealed that these proteins most likely contain sorting information that is only present when the proteins are properly folded.
| Last modified: | 17 November 2015 12.59 p.m. |
More news
-
10 September 2025
Funding for Feringa and Minnaard from National Growth Fund project Big Chemistry
Two UG research projects have received funding from the National Growth Fund project Big Chemistry via NWO.
-
09 September 2025
The carbon cycle as Earth’s thermostat
Earth's natural carbon cycle becomes unbalanced if we, humans, continue to release extra carbon dioxide (CO2) into the atmosphere. In this overview article about the carbon cycle, you can find out how Earth generally keeps itself in balance and how...
-
09 September 2025
Carbon dioxide’s fingerprint
In the year 2000, Harro Meijer, Professor of Isotope Physics at the University of Groningen, set up the Lutjewad Measurement Station near Hornhuizen. There, researchers from Groningen are mapping where CO2 in the atmosphere originates and where it...