Interplay between glucose, fatty acid and bile salt metabolism in mouse models of fatty liver

Promotie: mw. H.J. Herrema, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen

Proefschrift: Interplay between glucose, fatty acid and bile salt metabolism in mouse models of fatty liver

Promotor(s): prof.dr. F. Kuipers, prof.dr. M. Müller

Faculteit: Medische Wetenschappen

Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl

Interplay between glucose, fatty acid and bile salt metabolism in mouse models of fatty liver

Obesity is a major contributor to the global burden of the metabolic syndrome and chronic diseases like type 2 diabetes and cardiovascular diseases. Additionally, obesity and associated health problems have significant economic impact on health care systems. Strategies to prevent and treat these metabolic derangements are therefore urgently needed. For this, better insight in regulation of interorgan as well as intraorgan metabolic pathways is of key relevance. Studies described in this thesis provide insight in crosstalk between glucose, fatty acid and bile salt metabolism that is relevant for our understanding of the etiology and some of the consequences of metabolic diseases like type 2 diabetes.