The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
Promotie: mw. B.D. Roorda, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
Promotor(s): prof.dr. W.A. Kamps
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl
The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
This investigation showed that mesenchymal stem cells MSCs can promote lymphoma tumor growth (Daudi Burkitt). The results provide us more insight in the mechanisms by which MSCs can contribute to tumor growth. It was shown that MSCs protect tumor cells against cell death, and that this affect can be abolished by administration of the drug PTK. In addition, it was found that p27KIP1 plays an important role in the promotion of Burkitt lymphoma growth in response to micro-environmental factors. Our results indicate that p27KIP1 and its upstream regulators may be important targets in the treatment of Burkitt lymphoma.
| Last modified: | 13 March 2020 01.14 a.m. |
More news
-
05 March 2025
Women in Science
The UG celebrates International Women’s Day with a special photo series: Women in Science.
-
16 December 2024
Jouke de Vries: ‘The University will have to be flexible’
2024 was a festive year for the University of Groningen. In this podcast, Jouke de Vries, the chair of the Executive Board, looks back.
-
10 June 2024
Swarming around a skyscraper
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...