Skip to ContentSkip to Navigation
About us Latest news News News articles

The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth

10 March 2010

Promotie: mw. B.D. Roorda, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Proefschrift: The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth

Promotor(s): prof.dr. W.A. Kamps

Faculteit: Medische Wetenschappen

Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl

The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth

This investigation showed that mesenchymal stem cells MSCs can promote lymphoma tumor growth (Daudi Burkitt). The results provide us more insight in the mechanisms by which MSCs can contribute to tumor growth. It was shown that MSCs protect tumor cells against cell death, and that this affect can be abolished by administration of the drug PTK. In addition, it was found that p27KIP1 plays an important role in the promotion of Burkitt lymphoma growth in response to micro-environmental factors. Our results indicate that p27KIP1 and its upstream regulators may be important targets in the treatment of Burkitt lymphoma.

Last modified:13 March 2020 01.14 a.m.
View this page in: Nederlands

More news

  • 13 October 2023

    Moniek Tromp appointed Captain of Science of the Top Sector Chemistry

    Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.

  • 12 September 2023

    Art in times of AI

    Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...

  • 28 August 2023

    Harish Vedantham and Casper van der Kooi nominated for 'Wetenschapstalent 2023'

    Harish Vedantham and Casper van der Kooi have been nominated by New Scientist for Wetenschapstalent 2023 (Science Talent 2023). This election is meant to give young scientists and their research a stage.