The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
Promotie: mw. B.D. Roorda, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
Promotor(s): prof.dr. W.A. Kamps
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl
The role of bone marrow-derived mesenchymal stem cells in lymphoma tumor growth
This investigation showed that mesenchymal stem cells MSCs can promote lymphoma tumor growth (Daudi Burkitt). The results provide us more insight in the mechanisms by which MSCs can contribute to tumor growth. It was shown that MSCs protect tumor cells against cell death, and that this affect can be abolished by administration of the drug PTK. In addition, it was found that p27KIP1 plays an important role in the promotion of Burkitt lymphoma growth in response to micro-environmental factors. Our results indicate that p27KIP1 and its upstream regulators may be important targets in the treatment of Burkitt lymphoma.
| Last modified: | 13 March 2020 01.14 a.m. |
More news
-
04 July 2025
University of Groningen awards different prizes during Ceremony of Merits
The UG awarded different prizes to excellent researchers and students during the Ceremony of Merits on 4 July 2025.
-
02 July 2025
Relinde Weil reappointed as a member of the Supervisory Board UG
The Minister of Education has reappointed Relinde Weil for a second term as a member of the Supervisory Board of the University of Groningen.
-