Skip to ContentSkip to Navigation
About usNews and EventsNews articles

High dimensional data analysis for new insight in ovarian cancer phenotypes

03 February 2010

PhD Ceremony: dhr. R.S.N. Fehrmann, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: High dimensional data analysis for new insight in ovarian cancer phenotypes

Promotor(s): prof.dr. A.G.J. van der Zee, prof.dr. E.G.E. de Vries

Faculty: Medical Sciences

Contact: via the UMCG, tel. 050-361 2200, e-mail:

This thesis focuses on the identification of gene-expression profiles, biological pathways and transcription factors that are associated with survival and chemo-resistance in ovarian cancer. We used currently available methods for predictive gene profiling identification, resulting in an 86-gene profile that was associated with overall survival. We also show that gene expression can be conceptualized as a process influenced by a limited set of Transcriptional System Regulators (TSRs). In addition, we show that an expression profile of an individual microarray can be fairly well predicted from only 50 TSR scores (TSR profiling), summarizing the signal of thousands of individual genes in just 50 component scores.

Last modified:15 September 2017 3.39 p.m.
printView this page in: Nederlands

More news

  • 11 July 2019

    Major companies’ annual reports too vague about climate impact

    Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...

  • 08 July 2019

    UG permanently closes Yantai project

    The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.

  • 03 July 2019

    Cheap train tickets boost public transport use but reduce customer satisfaction

    Offers of cheap single train tickets through retailers such as Kruidvat or Etos have a positive impact on the number of kilometres travelled by rail. This impact is much bigger than that of more general TV, newspaper or magazine advertising. However,...