PhD ceremony: mw. S. Nagotu, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: The peroxisome proliferation machinery in yeast
Promotor(s): mw. prof.dr. I.J. van der Klei
Faculty: Mathematics and Natural Sciences
Contact: Shirisha Nagotu, tel. 050-363 23177, e-mail: email@example.com
Cell organelles are membrane bound structures that are present in eukaryotic cells (e.g. yeast, plant or mammalian cells). These organelles perform highly specialized functions, such as the generation of energy or the recycling of waste material. Peroxisomes are cell organelles that are capable to perform various chemical reactions. In man they are involved in the degradation of specific fatty acids as well as in the production of certain lipids. The importance of these pathways is stressed by the observation that several human disorders exist due to defects in the formation of these organelles.
The topic of this thesis is to answer the question how peroxisomes are formed in a cell. Are they formed by fission of pre-existing ones or can they be derived from another type of organelle, the endoplasmic reticulum? And what are the proteins involved in these processes?
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