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Dysfunction of stress responsive systems in somatization

20 January 2010

PhD Ceremony: mw. L.M. Tak, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Dysfunction of stress responsive systems in somatization

Promotor(s): prof.dr. J. Ormel, prof.dr. J.P.J. Slaets

Faculty: Medical Sciences

Contact: via the UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl

In this thesis, we perform meta-analyses and prospective population-based studies to investigate the association between dysfunction of stress responsive systems and somatization. We conclude that dysfunction of stress responsive systems is not a necessary factor for somatization in general. However, alterations in the three stress responsive systems, such as lowered cardiac vagal activity, hypocortisolism, and possibly low-grade immune activation, may be pivotal in the etiology in specific groups of patients with somatization. Such subgroups need to be better identified in order to improve treatment strategies.

Last modified:13 March 2020 01.17 a.m.
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