Promotie: mw. A.L. Bartels, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: Pathogenetic mechanisms in Parkinson's disease: studies with Positron Emission Tomography
Promotor(s): prof.dr. K.L. Leenders, prof.dr. R.A. Dierckx
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl
Pathogenetic mechanisms in Parkinson's disease: studies with Positron Emission Tomography
Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a prevalence of approximately 1 % in the population above 65 years. For the development of treatments to prevent or slow this progressive disease, more knowledge of the pathogenesis is necessary. In this thesis, Positron Emission Tomography (PET) imaging is used to study the role of blood-brain barrier (BBB) dysfunction and neuroinflammation as possible contributory factors in PD pathogenesis. We found that decreased BBB P-gp function does not play a primary role in PD development, but may be involved in the progression of neurodegenerative disease. In a toxic PD animal model, treatment with a COX-2 inhibitor did not show diminished microglia activation, but did show decreased up-regulation of P-gp expressing vasculature after the toxic lesion.
Prof. Moniek Tromp has been appointed Captain of Science of the Chemistry Top Sector by the Minister of Economic Affairs and Climate Policy. As from 1 July 2023, she succeeded Prof. Bert Weckhuysen from Utrecht University.
Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...
Harish Vedantham and Casper van der Kooi have been nominated by New Scientist for Wetenschapstalent 2023 (Science Talent 2023). This election is meant to give young scientists and their research a stage.
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether you want to accept
or reject other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information