prof. dr. W. (Wim) Timens

Professor

Faculty of Medical Sciences

Telephone:

+31 50 361 0020

E-mail:

w.timens umcg.nl

Homepage ORCID Research Portal

Publications

3D Culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes

Migulina, N., de Hilster, R. H. J., Bartel, S., Vedder, R. H. J., van den Berge, M., Nagelkerke, A., Timens, W., Harmsen, M. C., Hylkema, M. N., Brandsma, C-A. & Burgess, J. K., Jan-2024, In: American Journal of Physiology - Cell Physiology. 326, 1, p. C177–C193 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe COPD

Khalenkow, D., Brandsma, C-A., Timens, W., Choy, D. F., Grimbaldeston, M. A., Rosenberger, C. M., Slebos, D-J., Kerstjens, H. A. M., Faiz, A., Koppelman, G. H., Nawijn, M. C., van den Berge, M. & Guryev, V., 5-Feb-2024, (E-pub ahead of print) In: American Journal of Respiratory Cell and Molecular Biology. 48 p.

Research output: Contribution to journal › Article › Academic › peer-review

COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities

Faiz, A., Wiersma, V. R., Salzbrunn, J. B., Brandsma, C-A., Timens, W., Burgess, J. K., van den Berge, M., Slebos, D-J., Guryev, V. & Pouwels, S. D., 3-Jan-2024, (E-pub ahead of print) In: Archivos de bronconeumologia.

Research output: Contribution to journal › Letter › Academic › peer-review

Developments in predictive biomarker testing and targeted therapy in advanced stage non-small cell lung cancer and their application across European countries

de Jager, V. D., Timens, W., Bayle, A., Botling, J., Brcic, L., Büttner, R., Fernandes, M. G. O., Havel, L., Hochmair, M. J., Hofman, P., Janssens, A., Johansson, M., van Kempen, L., Kern, I., Lopez-Rios, F., Lüchtenborg, M., Machado, J. C., Mohorcic, K., Paz-Ares, L., Popat, S., & 5 othersRyška, A., Taniere, P., Wolf, J., Schuuring, E. & van der Wekken, A. J., Mar-2024, In: The Lancet Regional Health - Europe. 38, 16 p., 100838.

Research output: Contribution to journal › Review article › peer-review

Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep

Steinkühler, T., Yang, S., Hu, M. A., Jainandunsing, J. S., Jager, N. M., Erasmus, M. E., Struys, M. M. R. F., Bosch, D. J., van Meurs, M., Jabaudon, M., Richard, D., Timens, W., Leuvenink, H. G. D. & Nieuwenhuijs-Moeke, G. J., 19-Feb-2024, In: International Journal of Molecular Sciences. 25, 4, 13 p., 2413.

Research output: Contribution to journal › Article › Academic › peer-review

Future perspective for the application of predictive biomarker testing in advanced stage non-small cell lung cancer

de Jager, V. D., Timens, W., Bayle, A., Botling, J., Brcic, L., Büttner, R., Fernandes, M. G. O., Havel, L., Hochmair, M., Hofman, P., Janssens, A., van Kempen, L., Kern, I., Machado, J. C., Mohorčič, K., Popat, S., Ryška, A., Wolf, J., Schuuring, E. & van der Wekken, A. J., Mar-2024, In: The Lancet Regional Health - Europe. 38, 9 p., 100839.

Research output: Contribution to journal › Review article › peer-review

Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis

Putri, K. S. S., Adhyatmika, A., Boorsma, C. E., Habibie, H., Ruigrok, M. J. R., Heukels, P., Timens, W., de Jager, M. H., Hinrichs, W. L. J., Olinga, P. & Melgert, B. N., 20-Apr-2024, (E-pub ahead of print) In: Lung.

Research output: Contribution to journal › Article › Academic › peer-review

The neo-open reading frame peptides that comprise the tumor framome are a rich source of neoantigens for cancer immunotherapy

Martin, M. V., Aguilar-Rosas, S., Franke, K., Pieterse, M., van Langelaar, J., Schreurs, R. RCE., Bijlsma, M. F., Besselink, M. G., Koster, J., Timens, W., Khasraw, M., Ashley, D. M., Keir, S. T., Ottensmeier, C. H., King, E. V., Verheij, J., Waasdorp, C., Valk, P. J. M., Engels, S. AG., Oostenbach, E., & 16 othersvan Dinter, J. T., Hofman, D. A., Mok, J. Y., van Esch, W. J. E., Wilmink, H., Monkhorst, K., Verheul, H. M. W., Poel, D., Hiltermann, T. J. N., van Kempen, L. C., Groen, H. J., Aerts, J. G. J. V., van Heesch, S., Lowenberg, B., Plasterk, R. & Kloosterman, W. P., 4-Apr-2024, (E-pub ahead of print) In: Cancer immunology research. 41 p.

Research output: Contribution to journal › Article › Academic › peer-review

Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts

Nizamoglu, M., Alleblas, F., Koster, T., Borghuis, T., Vonk, J. M., Thomas, M. J., White, E. S., Watson, C. K., Timens, W., El Kasmi, K. C., Melgert, B. N., Heijink, I. H. & Burgess, J. K., 15-Mar-2024, In: Acta Biomaterialia. 177, p. 118-131 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

A bronchial gene signature specific for severe COPD that is retained in the nose

van Nijnatten, J., Faiz, A., Timens, W., Guryev, V., Slebos, D-J., Klooster, K., Hartman, J. E., Kole, T., Choy, D. F., Chakrabarti, A., Grimbaldeston, M., Rosenberger, C. M., Kerstjens, H., Brandsma, C-A. & van den Berge, M., Nov-2023, In: ERJ Open Research. 9, 6, 12 p., 00354-2023.

Research output: Contribution to journal › Article › Academic › peer-review