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University Medical Center Groningen

K. Dimitriadis

Associate Professor
Research interests Publicaties

Research interests

Dr. Constantinos Demetriades is a Molecular Cell Biologist and a European Research Council (ERC) Grantee. Currently, he holds an Associate Professor position in ERIBA/UMCG in Groningen. Previously he served as Max Planck Research Group Leader at the MPI-AGE in Cologne. His work focuses on the intricate molecular and cellular mechanisms of nutrient sensing and growth control, mainly via the regulation of the master cellular nutrient sensor and growth coordinator: the mTOR kinase. Dr Demetriades’ work has elucidated the mechanistic details of mTOR inactivation in response to nutrient starvation and has revealed how information from multiple, diverse, cellular stresses is integrated to control cellular physiology. The vision of the Demetriades group at the MPI-AGE is to understand 1) how cells sense the presence or the absence of nutrients in their environment to adjust their growth and metabolism accordingly, 2) how the dysregulation of these cellular mechanisms contributes to the development of human diseases (cancer, diabetes, neurological disorders) and the ageing process, and 3) how we can intervene pharmacologically to target these mTOR-related conditions.

Publicaties

GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi

Nüchel, J., Omidi, M., Fernandes, S. A., Tauber, M., Pohl, S., Plomann, M. & Demetriades, C., 16-apr.-2026, (E-pub ahead of print) In: Embo Reports.

Onderzoeksoutput › › peer review

An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies

Perri, G., French, C., Agostinis-Sobrinho, C., Anand, A., Antarianto, R. D., Arai, Y., Baur, J. A., Cauli, O., Clivaz-Duc, M., Colloca, G., Demetriades, C., De Lucia, C., Di Gessa, G., Diniz, B. S., Dotchin, C. L., Eaglestone, G., Elliott, B. T., Espeland, M. A., Ferrucci, L. & Fisher, J., Grammatopoulos, D. K., Hardiany, N. S., Hassan-Smith, Z., Hastings, W. J., Jain, S., Joshi, P. K., Katsila, T., Kemp, G. J., Khaiyat, O. A., Lamming, D. W., Gallegos, J. L., Madeo, F., Maier, A. B., Martin-Ruiz, C., Martins, I. J., Mathers, J. C., Mattin, L. R., Merchant, R. A., Moskalev, A., Neytchev, O., Ni Lochlainn, M., Owen, C. M., Phillips, S. M., Pratt, J., Prokopidis, K., Rattray, N. J. W., Rúa-Alonso, M., Schomburg, L., Scott, D., Shyam, S., Sillanpää, E., Tan, M. M. C., Teh, R., Tobin, S. W., Vila-Chã, C. J., Vorluni, L., Weber, D., Welch, A., Wilson, D., Wilson, T., Zhao, T., Philippou, E., Korolchuk, V. I. & Shannon, O. M., mei-2025, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 80, 5, 12 blz., glae297.

Onderzoeksoutput › › peer review

Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging

Bubb, K., Etich, J., Probst, K., Parashar, T., Schuetter, M., Dethloff, F., Reincke, S., Nolte, J. L., Krüger, M., Schlötzer-Schrehard, U., Nüchel, J., Demetriades, C., Giavalisco, P., Riemer, J. & Brachvogel, B., 18-apr.-2025, In: Science Advances. 11, 16, 21 blz., eads1842.

Onderzoeksoutput › › peer review

The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

Fernandes, S. A., Pan, J., Terziyska, D. S., Koyuncu, S., Ding, X., Németh, I. B., Wilhelm, S., Nüchel, J., Al-Gburi, S., Gonidas, C., Pasparakis, M., Mosialos, G., Széll, M., Teleman, A. A., Eming, S. A., Vilchez, D. & Demetriades, C., 2-sep.-2025, BioRxiv, (bioRxiv).

Onderzoeksoutput: Voordruk ›

mTORC1 activity licenses its own release from the lysosomal surface

Acharya, A. & Demetriades, C., 21-nov.-2024, In: Molecular Cell. 84, 22, blz. 4385-4400.e7 24 blz.

Onderzoeksoutput › › peer review

Spatial and functional separation of mTORC1 signalling in response to different amino acid sources

Fernandes, S. A., Angelidaki, D. D., Nüchel, J., Pan, J., Gollwitzer, P., Elkis, Y., Artoni, F., Wilhelm, S., Kovacevic-Sarmiento, M. & Demetriades, C., nov.-2024, In: Nature Cell Biology. 26, 11, blz. 1918-1933 16 blz.

Onderzoeksoutput › › peer review

Codependencies of mTORC1 signaling and endolysosomal actin structures

Priya, A., Antoine-Bally, S., Macé, A. S., Monteiro, P., Sabatet, V., Remy, D., Dingli, F., Loew, D., Demetriades, C., Gautreau, A. M. & Chavrier, P., 2023, In: Science Advances. 9, 37, blz. 1-13 13 blz., add9084.

Onderzoeksoutput › › peer review

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

Nicastro, R., Brohée, L., Alba, J., Nüchel, J., Figlia, G., Kipschull, S., Gollwitzer, P., Romero-Pozuelo, J., Fernandes, S. A., Lamprakis, A., Vanni, S., Teleman, A. A., De Virgilio, C. & Demetriades, C., sep.-2023, In: Nature Cell Biology. 25, 9, blz. 1303-1318 16 blz.

Onderzoeksoutput › › peer review

mTORC1 activity negatively regulates human hair follicle growth and pigmentation

Suzuki, T., Chéret, J., Scala, F. D., Akhundlu, A., Gherardini, J., Demetrius, D. L., O'Sullivan, J. D. B., Kuka Epstein, G., Bauman, A. J., Demetriades, C. & Paus, R., 5-jul.-2023, In: Embo Reports. 24, 7, e56574.

Onderzoeksoutput › › peer review

Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor

Artoni, F., Grützmacher, N. & Demetriades, C., aug.-2023, In: Aging Cell. 22, 8, 15 blz., e13888.

Onderzoeksoutput › › peer review

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